About Dapoxetine

Dapoxetine is an oral prescription tablet that has the potential to cure premature ejaculation in men. Initially developed as a medication for depression, this Dapoxetine hydrochloride has been re-formulated to function as a selective serotonin reuptake inhibitor (SSRI). During clinical trials conducted on males 18 years and above, Dapoxetine has demonstrated to prolong their duration of their ejaculation period by three to four-folds and also provide more satisfaction to the partners engaged in sexual intercourse.
In other words, Dapoxetine has proved to be effective in enhancing the ejaculatory latency time and as a result perk up the quality of sex life of males confronted with premature ejaculation problems and their partners. Dapoxetine is a prescription drug and will be available only on prescription from a medical doctor. The drug’s generic name is Dapoxetine hydrochloride and is being manufactured by Johnson & Johnson. Presently, only a few European Union nations have approved the use of Dapoxetine for treating premature ejaculation and men affected with the problem may buy Priligy, the brand name of the drug in these countries.
On the other hand, the Food and Drug Administration (FDA) in the United States is currently examining the Phase III clinical trial reports of Dapoxetine and is expected to approve the use of the drug once it is satisfied regarding the side effects of using the oral pill. The drug is also yet to get approval in the United Kingdom and other parts of the world. It is expected that once the FDA approves its use for treating premature ejaculation, many countries will follow suit and people would be able to buy Dapoxetine with prescriptions or order online Dapoxetine.

Significance of Dapoxetine-

Premature ejaculation (PE) is considered to be the most common disorder among all male sexual dysfunctions. In fact, several studies have established that around 75 per cent of men across the globe have suffered from this symptom at some point in their life and it is more widespread among males in the age group of 18-30 years. Although premature ejaculation is not considered to be a disease, it may occur at any age among men. Premature ejaculation can destabilize relations between sexual partners and often even ruin marriages. In fact, studies have demonstrated that premature ejaculation is responsible for more than 50 per cent of all divorces in the United States. Moreover, premature ejaculation may also result in erectile dysfunction, diminishing libido, decline in sexual pleasure for both partners, inability to achieve orgasm, social humiliation as well as lower self-esteem.
Broadly speaking, premature ejaculation is described as the occurrence of early ejaculation in men during sexual intercourse. It can happen before or soon after penetration of penis or earlier than the preferred time of both sexual partners. In fact, occasional premature ejaculation is not an issue for concern, but when it happens on a regular basis, it is essential to seek medical help. In such situations, drugs like Dapoxetine can help men to fight premature ejaculation and lead a healthy, happy and contended sexual life. In fact, Dapoxetine hydrochloride is the first medication of its kind for treating this male sexual disorder and it is expected that once approved by the FDA, it will overshadow the popularity of Viagra that is used to treat erectile dysfunction among men.

Reasons for Premature Ejaculation-

It is interesting to note that though premature ejaculation is the most common sexual problem faced by men worldwide, scientists are yet to ascertain what is precisely responsible for the symptom. As far as our present knowledge regarding premature ejaculation is concerned, it may occur owing to psychological as well as neurobiological reasons. The psychological reasons are cited to be stress, sexual conditions and regularity of sexual activity, while the neurological causes may include low serotonin neurotransmission or hypersensitivity. As computed by the American Medical Association's Dictionary of Sexual Dysfunction, premature ejaculation takes place within two minutes of the beginning of sexual intercourse, while mature ejaculation occurs more than seven minutes after the penile introduction.
Whatever may be the cause, they may be effectively treated with SSRIs like Dapoxetine. While Dapoxetine is not an aphrodisiac, it has the ability to enhance serotonin levels in the central nervous system. While Dapoxetine hydrochloride has the potential to enhance men’s control over ejaculation and their satisfaction during sexual intercourse, the drug does not augment sex drive or libido among men. As premature ejaculation is an embarrassing issue for most men, they don’t want to discuss the problem with anyone, including their physicians. However, with the availability of Dapoxetine, it is believed that men will be more prepared to discuss their premature ejaculation problems with the gynecologists.

Dapoxetine Clinical Trials-

Clinical trials of Dapoxetine covered 2,614 men in the age group of 18-77 years having premature ejaculation problems. These men, who retained monogamous sexual bond with their partners for six months or more, were given 30 mg or 60 mg of Dapoxetine or a placebo daily for a period of more than three months or 12 weeks. At the end of the period, it was found that men who were given Dapoxetine not only experienced a three-fold increase in the duration of sexual intercourse, but also more pleasure from their sexual activity.
According to Dr. Richard Longwell, chairman and managing director of the Department of Urologic Surgery at the University of Minnesota, the development of Dapoxetine puts an end to the frustration of men with premature ejaculation problems and also that of their sexual partners. He asserted that Dapoxetine not only inhibits orgasm, but also increases sexual satisfaction. In the clinical trial mentioned above the percentage of men rating control over ejaculation as "OK to awesome" enhanced from a mere 2.5 per cent before taking Dapoxetine to 51.8 per cent after taking it. Dr. Longwell further observed that Dapoxetine was equally effective in delaying orgasm in men who prefer self sex. Among men who have sex with other people, the percentage of their partners who reported feeling satisfied by sex increased from 25 per cent without taking Dapoxetine to 47 per cent with the wonder drug. In fact, the potential social benefits of this Dapoxetine hydrochloride are considerable – it's fast-acting while producing few side-effects.

Dapoxetine Dosage-

Dapoxetine or Priligy, the brand name of the drug in Europe, is to be taken only once in 24 hours. It is an oral pill that will be available only with valid prescriptions from qualified physicians. The normal dosage for Dapoxetine hydrochloride or Priligy is 30 mg or 60 mg depending on the patient and his premature ejaculation problems. However, the dosage may be increased to 100 mg later depending on the physician’s recommendation. Dapoxetine or Priligy pills are to be taken wholly with a glass of water one to one-and-a-half hours prior to sexual intercourse.

Dapoxetine Side Effects-

Dapoxetine hydrochloride belongs to the SSRI family of drugs that have a short half-life. In other words, this means that the patients' plasma receives it quickly and the plasma levels are normal again after about 1-2 hours. Nevertheless, premature ejaculation treatment with Dapoxetine is not free of side effects. The most common aftereffects of using Dapoxetine hydrochloride include nausea, headache, diarrhea and dizziness. While 8.7 per cent men taking low dose (30 mg) Dapoxetine experienced nausea, 20.1 per cent of men using high dose (60 mg or 100 mg) of the drug had the problem. In fact, during the studies it was found that the side effects were more frequent in patients using Dapoxetine 100 mg (16.1 per cent) compared to those taking Dapoxetine 60 mg (5.6 per cent). Depending on this reaction and acceptability of the drug, scientists used the 60 mg dose of Dapoxetine for the study that is continuing on a large-scale.

Dapoxetine Availability-

Thus far, five European nations, including Finland, Sweden, Portugal, Austria and Germany, have approved the use of Dapoxetine for treating premature ejaculation. The drug will be sold as ‘Priligy’ in these countries and is expected to be made available in licensed pharmacies following all local regulatory measures related to packaging and pricing are finalized. In fact, the government authorities in these countries have warned the people of the consequences of using fake Priligy (Dapoxetine) and advised them to buy Priligy only with valid prescriptions and from licensed pharmacies.
On the other hand, the Food and Drug Administration (FDA) in the United States is currently reviewing an application seeking the approval for using Dapoxetine to treat premature ejaculation. It is expected that it will take another few months before the Dapoxetine is available in the U.S. Patients in the United States and Canada will only be able to buy Dapoxetine or order online Dapoxetine only once the FDA approval comes through. Till then ordering online Dapoxetine from Internet pharmacies may be too risky. It is believed that once the FDA approves the use of Dapoxetine in the United States, many other countries worldwide will follow suit.